n CME : Your SA Journal of CPD - Long-term consequences of antiretroviral therapy : main article
|Article Title||Long-term consequences of antiretroviral therapy : main article|
|© Publisher:||Health and Medical Publishing Group (HMPG)|
|Journal||CME : Your SA Journal of CPD|
|Author||W.D. Francois Venter, Prudence Ive and Nkhangweni William Mmbara|
|Publication Date||May 2005|
|Pages||238 - 244|
|Keyword(s)||Antiretroviral therapy, Lactic acidosis, Lipodystrophy, Long-term consequences, Osteopenia, Osteoporosis and Peripheral neuropathy|
Common sense in the management of lipodystrophy seems prudent. Behaviour modification, especially smoking and weight reduction, should be encouraged. Metabolic complications should be treated according to conventional guidelines for HIV-negative populations, but with regard for drug interactions with ART. Avoid PIs with atherogenic profiles in patients with other cardiovascular risk factors. <br>Identify lactic acidosis and peripheral neuropathy early. The best tool is a switched-on patient, who can let the astute clinician know well before the development of critical illness. <br>AIDS is a disease with 100% mortality if untreated. ART makes the vast majority of HIV-infected people better. Cardiovascular disease is treatable in most cases, and risk factors easily identified and addressed. Lipodystrophy, lactic acidosis, and peripheral neuropathy are usually identifiable by the informed patient and clinician. Use ART correctly, and deal with the consequences using clinical common sense.
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