n CME : Your SA Journal of CPD - Clinical and laboratory evaluation of adverse reactions to drugs : main article

Volume 23, Issue 9
  • ISSN : 0256-2170



Adverse reactions to drugs are common, and almost any drug can cause an adverse reaction. <br>True drug allergies occur when there is an allergic/hypersensitivity reaction with an immune basis. There is usually antibody production and/or histamine release (or sulphidoleukotriene release). <br>Most adverse reactions to drugs cause minor skin rashes. <br>The drug that most commonly causes reactions is penicillin. Penicillin reactions may affect most organs or systems and may cause a range of pathologies. <br>In suspected anaphylaxis, serial tryptase measurements may confirm the diagnosis. <br>There is no laboratory test to confirm SJS. It is diagnosed clinically and the drugs should not be reintroduced.

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