n CME : Your SA Journal of CPD - New developments in the investigation and management of chronic urticaria : main article

Volume 23, Issue 9
  • ISSN : 0256-2170



Autoimmune urticaria, caused by autoantibodies to the high-affinity receptor for IgE or to IgE itself, occurs in 30 - 40% of patients with CU. <br>The diagnosis rests mainly on clinical suspicion in patients with the most severe presentations of CU and without any known cause or physical trigger. <br>Better laboratory assays (to detect these autoantibodies) need to be routinely available to facilitate diagnosis. <br>Currently, the new-generation antihistamines remain the mainstay of treatment for CU. <br>The use of immunomodulatory therapy may be beneficial for some patients with autoimmune urticaria. <br>With the ongoing development of novel agents for the treatment of allergic disease, perhaps new agents will be discovered that are highly effective for the treatment of CU and safe for long-term use.

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