n CME : Your SA Journal of CPD - Dosing in the obese patient : clinical pharmacology




Extracted from text ... CLINICAL PHARMACOLOGY clinical pharmacology many drugs are dosed according to the weight of the patient. The amount of drug per kilogram of body weight required to achieve therapeutic levels is usually derived from pharmacokinetic studies in normal-weight volunteers. obesity, defined as a body mass index (Bmi) > 30, is associated with numerous physiological changes which influence the manner in which the body interacts with drugs. Despite this, very few studies have been conducted to determine the correct dose requirements of individual drugs in obese individuals. as a result, it is difficult to decide what dose of a drug should ..


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