n CME : Your SA Journal of CPD - Asthma : primary therapies : main article




  • Anti-inflammatory therapy is the cornerstone of therapy in asthma.
  • Corticosteroids are the most effective anti-inflammatory agents.
  • Corticosteroids are available in different potencies - more severe disease is best managed with a more potent steroid.
  • Clinical therapeutic endpoints (the goals of asthma management) are a useful surrogate of control of airway inflammation and narrowing.
  • Inhaled corticosteroids plus long-acting β-antagonist are the most effective agents for uncontrolled asthma.
  • Most MDIs contain CFCs - these are being phased out and replaced with HFA/dry-powder devices.
  • MDIs are the best way to deliver therapy as small, effective doses can be delivered to the appropriate site, making them cost-effective and limiting systemic side-effects.
  • Patient education and reinforcement is crucial - the better patients utilise their MDIs the better the clinical effect.


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