n CME : Your SA Journal of CPD - Combined oral contraception and broad-spectrum antibiotic use : clinical pharmacology

Volume 27, Issue 10
  • ISSN : 0256-2170



The combined oral contraceptive (COC) is among the most widely used methods of contraception worldwide. The COC is easy to use and extremely effective. Women using the COC may sooner or later require an antibiotic, raising the concern of the unsought COC-antibiotic interaction that may decrease efficacy of the COC and lead to an unwanted pregnancy. In order to address the COC-antibiotic interaction and its potential risk adequately, some knowledge of COC metabolism is required.

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