n CME : Your SA Journal of CPD - The role of epigenetics in the origin of congenital heart disease : more about... paediatric cardiology




The past decade has seen a remarkable explosion of insights into the control of heart development. This has come about as a consequence of the temporal confluence of several research domains: the better delineation of syndromic congenital heart disease (see article in this issue), the completion of the Human Genome Project in 2003, the remarkable advances in molecular embryology and a deeper understanding of genetic evolution. It is against this background, and by combining data from anatomical embryology, early fetal myocardial function, and fetal blood flow with a new understanding of the genetically development of cardiac chambers (the independent, regional development of cardiac chambers under distinct genetic control) that the ballooning model of heart development1 has revolutionised our understanding of normal heart development.


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