n CME : Your SA Journal of CPD - Prostate specific antigen : a useful but limited marker for prostate cancer

Volume 30, Issue 7
  • ISSN : 0256-2170



Prostate cancer (Pca) is the second most common cause of cancer worldwide. The incidence rates vary geographically, with the highest rates observed in highly resourced countries. Although lower rates are observed in developing countries, sub-Saharan Africa included, the mortality rate is reported to be higher. This is partly attributable to lack of screening programmes and presentation in advanced stages of the disease in the majority of cases. Like other cancers, the target in the management of Pca is early detection when cure is more likely. Prostate specific antigen (PSA) is widely used as a tumour marker for Pca, both for the detection and staging of the disease, as well as in determining prognosis and monitoring treatment response.

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