n CME : Your SA Journal of CPD - The South African Bone Marrow Registry - role in providing unrelated donors for allogeneic stem cell transplantation : more about... immunology




The South African Bone Marrow Registry (SABMR) was established in 1991 in Cape Town, as a non-profit organisation at the initiative of professors Ernette du Toit and Peter Jacobs, to provide human leukocyte antigen (HLA) matched unrelated donors (MUDs) for South African (SA) patients.

Allogeneic bone marrow and now peripheral blood stem cell transplantation has come a long way since the work of E Donall Thomas in Seattle in the early 1950s. These studies showed that by using HLA-matched sibling donors it was possible to cure certain haematological and metabolic diseases. These include acute and chronic myeloid leukaemia, myeloid dysplasia, lymphomas, multiple myeloma, aplastic anaemia, haemoglobinopathies, thalassaemia, Fanconi's anaemia and storage diseases.


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