n CME : Your SA Journal of CPD - Innate immunity




Mechanical barriers presented by the skin and mucus membranes, together with anti-infective chemicals and enzymes present on their surfaces, impede the access of potential pathogens to the epithelium and underlying tissues. If these are subverted, the interactions of invasive pathogens with various types of pathogen recognition receptors on epithelial cells and resident cells of the innate immune system, especially macrophages, initiate a localised inflammatory response characterised by an early influx of blood neutrophils.


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