n CME : Your SA Journal of CPD - Chemotherapy in eye cancer

Volume 31, Issue 4
  • ISSN : 0256-2170



Cancer chemotherapy research is a multibillion-dollar industry, which began in the early 20th century when mustard gas was used in World War I as a chemical warfare agent and was found to be a suppressor of haematopoiesis.

Chemotherapeutic drugs work by impairing mitosis at the DNA and/or RNA level. The drugs are cytotoxic and kill cells by promoting apoptosis or frank necrosis. Chemotherapy may be intended to be either curative or palliative and is therefore used in several different ways. Chemotherapeutic drugs can be used in combination with radiation therapy and surgery, for chemoreduction preoperatively, and postoperatively when there is residual tumour or risk of recurrence, and as palliative therapy to decrease the tumour load and increase life expectancy.

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