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- Journal of Endocrinology, Metabolism and Diabetes in South Africa
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- Volume 10, Issue 1, 2005
Journal of Endocrinology, Metabolism and Diabetes in South Africa - Volume 10, Issue 1, 2005
Volume 10, Issue 1, 2005
Source: Journal of Endocrinology, Metabolism and Diabetes in South Africa 10, pp 2 –3 (2005)More Less
Extracted from text ... NEWS ? NEWS ? NEWS ? NEWS ? NEWS ? NEWS Clinical rules not useful in predicting osteoporosis in women Clinical prediction rules that take into account various risk factors, are not particularly useful in identifying women with a high probability of having osteoporosis, new research shows. However, because the sensitivity of these rules is high, a negative result may identify women for whom bone mineral density (BMD) testing is unnecessary. The US Preventive Service Task Force currently recommends routine osteoporosis screening with BMD testing for all women 65 years of age or older. For younger postmenopausal women, however, it ..
Author Roy ShiresSource: Journal of Endocrinology, Metabolism and Diabetes in South Africa 10 (2005)More Less
Extracted from text ... JEMDSA 4 The 2005 SEMDSA (Society for Endocrinology, Metabolism and Diabetes of South Africa) and National Osteoporosis Foundation (NOF) conferences will be held this year in Sandton on 9 - 12 April 2005. SEMDSA and NOF 2005 promise to be exciting and stimulating events. They will include numerous plenary and interactive meet-the-professor sessions as well as high-quality oral and poster presentations. This year a total of seven eminent international guest speakers from the USA and UK will be participating. The emphasis will be clinical, but basic science will also be catered for. The confirmed guest speakers are Derek Le Roith ..
Source: Journal of Endocrinology, Metabolism and Diabetes in South Africa 10, pp 6 –9 (2005)More Less
<i>Background.</i> Little is known about the frequency of thyroid dysfunction (TD) associated with amiodarone therapy in southern Africa. <br><i>Objectives.</i> To determine the incidence of TD in a cohort of patients initiated on amiodarone therapy at a cardiac clinic in Cape Town, South Africa, believed to be an iodine-replete area. <br><i>Patients.</i> Pharmacy records were used to obtain the names of patients who received amiodarone between November 1999 and December 2002. <br><i>Results.</i> The sample size was 194, but data analysis was limited to the 163 patients for whom there were complete data. The mean age ± standard deviation (SD) was 59.0 ± 15.0 years (range 22 - 89 years). There were 67 female and 96 male patients. The indications for amiodarone therapy were supraventricular tachycardias (N = 102, 62.6%), ventricular tachycardia (N = 55, 33.7%), and prophylaxis against tachycardias (N = 3, 1.8%). The indication was uncertain in 3 patients (1.8%). The median duration of amiodarone treatment was 679.0 days (quartile deviation (QD) 1 172 days, range 3 - 6 425 days) in the whole cohort. The median duration of amiodarone therapy until new TD was 943 days (QD 1 185 days), significantly longer than in patients who remained euthyroid (547 days, QD 1 135 days) (P = 0.05). There were 45 new TD cases (27.6%): 11 patients (6.7%) were thyrotoxic, 1(0.6%) transient thyrotoxicosis, 1 (0.6%) subclinical hyperthyroidism, 13 (8.0%) had subclinical hypothyroidism, 12 (7.4%) hypothyroidism and 7 (4.3%) had minor changes in thyroid function. <br><i>Conclusions.</i> We found a high incidence of new-onset TD, similar to the highest rates reported internationally. Local factors responsible for this need to be investigated.
Source: Journal of Endocrinology, Metabolism and Diabetes in South Africa 10, pp 11 –15 (2005)More Less
<i>Objectives.</i> To establish whether an experienced endocrinologist could screen accurately for diabetic retinopathy using mydriatic 60<sup>o</sup> fundus photographs compared with a reference standard, viz. the combined highest scores of two experienced ophthalmologists. <br><i>Design.</i> Retrospective review of 60<sup>o</sup> colour transparency photographs taken over a 6-year period. Retinopathy was graded in a standardised way. <br><i>Setting.</i> Patients attending the diabetic clinic at Johannesburg Hospital, South Africa. <br><i>Subjects.</i> Fifteen hundred and seventeen patients (2 446 eyes) formed the basis for the study. Patients were included if there was more than 50% readability of the fundus photographs. <br><i>Outcome measures.</i> Outcome measures were prevalence of any retinopathy and presence of referable (severe) retinopathy. Inter-observer agreement was measured using the kappa statistic, and sensitivity and specificity of the screener were evaluated. <br><i>Results.</i> The prevalence of retinopathy at the clinic was approximately 30%, but only about 12% was severe enough to warrant referral to the ophthalmology outpatient department. The endocrinologist was very accurate in determining cases requiring referral; there was 97% agreement with the reference standard, viz. the combined highest score of two experienced ophthalmologists (gold standard). Correlation on the determination of any retinopathy was less accurate (80% agreement), mostly owing to the endocrinologist reporting more isolated microaneurysms than the ophthalmologists. The screening method used gave a sensitivity of 83% and specificity of 99% which are within recommended standards. <br><i>Conclusions.</i> The screening strategy using a mydriatic fundus camera at the diabetic clinic was found to be effective and accurate and greatly reduced the number of possible referrals to the ophthalmology outpatient department.
Source: Journal of Endocrinology, Metabolism and Diabetes in South Africa 10, pp 18 –44 (2005)More Less
Extracted from text ... Clinical and Biochemical Characteristics based on Body Mass Index (BMI) categories in South African Indians: Results from a Population Study. AA Motala, FJ Pirie, E Gouws, MAK Omar. University of KwaZulu-Natal, Medical Research Council, Durban, South Africa. A 10 year follow-up study of glucose tolerance in South African Indians aged >15 years, allowed for examination of clinical and biochemical characteristics based on body mass index (BMI) (kg/m2) categories. All subjects had anthropometric, demographic and biochemical measurements including a modified 75g OGTT. The 2000 WHO classification for overweight and obesity and the 1998 WHO criteria for disorders of glycaemia were used. ..
Source: Journal of Endocrinology, Metabolism and Diabetes in South Africa 10, pp 44 –45 (2005)More Less
Extracted from text ... JEMDSA 44 The INITIATE study: NovoMix 30 shows improved blood glucose control compared with insulin glargine NovoMix 30, a premix insulin analogue, is more effective than insulin glargine in helping people with type 2 diabetes, who are new to insulin therapy, achieve targeted HbA1c levels, according to a study published in the February issue of Diabetes Care. A total of 66% of patients using NovoMix 30 reached target HbA1c levels, compared with only 40% receiving insulin glargine. 'This study demonstrates the value of initiating insulin therapy with a dualacting insulin analogue, particularly in patients with HbA1c values greater than 8.5%, ..
Author Ian CookSource: Journal of Endocrinology, Metabolism and Diabetes in South Africa 10, pp 47 –48 (2005)More Less
Extracted from text ... 47 JEMDSA To the Editor: It was with favourable interest that I read the recent articles on the treatment and prevention of the insulin resistance syndrome.1, 2 I was appreciative of the fact that the authors acknowledged that an increase in voluntary human energy expenditure is essential in the treatment and prevention of the insulin resistance syndrome. However, the lack of accuracy and clarity of the physical activity guidelines promoted by the authors detracted from the quality of the articles. I fully appreciate the vast scope that they attempted to cover, but regrettably, they relied either on only three studies3, ..