oa Journal of Endocrinology, Metabolism and Diabetes in South Africa - Strontium ranelate in the treatment of osteoporosis : editorial
Extracted from text ... May 2006, Vol. 11, No. 1 JEMDSA Osteoporotic fractures are a common and important cause of disability and death worldwide. Antiresorptive agents like the bisphosphonates or the oestrogen analogues have been shown in large randomised controlled trials (RCTs) to significantly reduce the rate of osteoporotic fractures. These agents do not, however, abrogate fractures or the deranged skeletal microarchitecture that characterises osteoporosis; they only modestly and often transiently increase bone mineral density (BMD), and are not free of sideeffects. Moreover, since bone formation and resorption are usually tightly coupled, even in most types of osteoporosis, the decrease in bone resorption ..
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