oa Journal of Endocrinology, Metabolism and Diabetes in South Africa - The adrenal gland in acute illness : editorial

Volume 11, Issue 1
  • ISSN : 1608-9677
  • E-ISSN: 2220-1009



Extracted from text ... JEMDSA May 2006, Vol. 11, No. 1 Defining normal adrenocortical responses (especially glucocorticoid responses) to various stimuli has been a topic of debate for many years in clinical endocrinology. The current view states that a serum total cortisol concentration of 550 nmol/l (20 ?g/dl) or more in response to stimulation with adrenocorticotrophic hormone (ACTH) indicates normal adrenal responsiveness and reserve and precludes the requirement for exogenous steroid supplementation.1 This is generally accepted for both the high-dose (250 ?g) and low-dose (1 ?g) ACTH stimulation tests, although blood levels of ACTH are significantly above physiological levels for the high-dose (1 ..

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