oa Journal of Endocrinology, Metabolism and Diabetes in South Africa - Statin benefits in people with cardiovascular risk factors only : commentary on a clinical trial



It is well established that HMG CoA reductase inhibitors or statins are effective for secondary prevention, that is in patients with established cardiovascular disease (CVD), but whether this benefit applies to those without CVD, in other words for primary prevention is uncertain. Previous studies have provided ambiguous answers on statin use in people at relatively low risk for cardiovascular disease. In addition there has been a debate about the safety and efficacy of statins in certain sub-groups such as the elderly (persons over age 65 or even 75 years of age), women, and those with diabetes mellitus.


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