oa Journal of Endocrinology, Metabolism and Diabetes in South Africa - Mitochondrial dysfunction and human immunodeficiency virus infection : review article
|Article Title||Mitochondrial dysfunction and human immunodeficiency virus infection : review article|
|© Publisher:||Medpharm Publications|
|Journal||Journal of Endocrinology, Metabolism and Diabetes in South Africa|
|Affiliations||1 University of Cape Town and 2 Red Cross Children's Hospital|
|Publication Date||Jan 2011|
|Pages||94 - 100|
|Keyword(s)||Highly active antiretroviral treatment, HIV, Mitochondrial DNA, Mitochondrial toxicity and Nucleoside reverse transcriptase inhibitor|
Human immunodeficiency virus (HIV) infection and the pharmacological treatment thereof have both been shown to affect mitochondrial function in a number of tissues, and each may cause specific organ pathology through specific mitochondrial pathways. HIV has been shown to kill various tissue cells by activation of mitochondrial apoptosis. Nucleoside analogues, used extensively to treat HIV infection, are known to influence a number of steps affecting mitochondrial DNA integrity. This review describes the basic physiology, pharmacology and pathophysiology of HIV infection and the nucleoside analogues regarding mitochondrial function and discusses the progress made in this field with respect to the measurement of these effects and the prediction of potential drug toxicity.
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