- A-Z Publications
- Journal of Endocrinology, Metabolism and Diabetes in South Africa
- Previous Issues
- Volume 17, Issue 1, 2012
Journal of Endocrinology, Metabolism and Diabetes in South Africa - Volume 17, Issue 1, 2012
Volume 17, Issue 1, 2012
Source: Journal of Endocrinology, Metabolism and Diabetes in South Africa 17, pp 1 –94 (2012)More Less
Author Brynne Ascott-EvansSource: Journal of Endocrinology, Metabolism and Diabetes in South Africa 17 (2012)More Less
As convener of the local organising committee, I have the pleasure of welcoming you to our 47th annual SEMDSA Congress, taking place in the President Hotel, next to the ocean in the beautiful suburb of Sea Point. The local organising committee has made a considerable effort to ensure the participation of some of the best speakers in basic and clinical diabetes and endocrinology. We have compiled a balanced programme, with superb topics delivered by fascinating speakers who are world experts in their fields. We have included some well-known alternatives to the routine oral presentations, such as the meet-the-expert session and poster session. However, both of these will be in new guises, which will hopefully make these sessions more stimulating to the audience. We have introduced a new facet to the programme, called the professorial debate, which is likely to be more stimulating then the Republican contender debates in the USA!
Author Stephen HoughSource: Journal of Endocrinology, Metabolism and Diabetes in South Africa 17 (2012)More Less
In 1990, the Society of Endocrinology Metabolism and Diabetes of South Africa (SEMDSA) and a diverse group of individuals interested in metabolic bone diseases in adults and children, held a combined congress in the Wilderness, a seaside village on the east coast of the Western Cape. The "boneheads" subsequently went on to establish the National Osteoporosis Foundation of South Africa (NOFSA) in 1993. This year, the Western Cape will again host a combined meeting. From 19-22 April, the 15th NOFSA and 47th SEMDSA Congress will be held at the President Hotel in Bantry Bay, Cape Town.
Author Jeannie BergSource: Journal of Endocrinology, Metabolism and Diabetes in South Africa 17 (2012)More Less
As a result of rising food prices, an economic crisis, and South Africa failing to reach the finals in the Rugby World Cup, 2011 was a tumultuous year.
In South Africa, last year was marked by the fact that a census was undertaken again. As we all know, in a similar vein to the drug trials that we read about, this cannot be successful if everyone is not counted.
Author D.J. BlomSource: Journal of Endocrinology, Metabolism and Diabetes in South Africa 17, pp 37 –42 (2012)More Less
Cardiovascular risk increases progressively with age. Statins in octogenarians may therefore potentially bring about large reductions in absolute risk. Epidemiological studies, however, show that statin prescription declines with age and is lowest in the oldest patients with the highest cardiovascular risk. Reasons for low statin utilisation in the elderly include safety concerns, doubts about the utility of statin therapy in those of advanced age and a paucity of definite trial evidence supporting statin prescription in octogenarians. Some of the more recently completed statin outcome trials have randomised patients as old as 82 years. A meta-analysis of secondary prevention, with patients aged 65-82 years at randomisation, supported statin prescription in this age group, as statin therapy was associated with relative risk reduction similar to that observed in younger patients. A Swedish registry study showed improved survival in octogenarians prescribed a statin following hospitalisation with an acute myocardial infarction. Currently there is no definite evidence that statin therapy prevents or ameliorates cognitive impairment or dementia. Statin therapy should be considered in octogenarians at high cardiovascular risk, taking into account factors such as biological vs. chronological age, life expectancy, quality of life, risk of interaction with medications taken for co-morbidities and the ability of the patient to take the statin safely.
Relationship between salivary androstenedione levels, body composition and physical activity levels in young girls : original researchSource: Journal of Endocrinology, Metabolism and Diabetes in South Africa 17, pp 44 –50 (2012)More Less
Background : High androgenic activity in adolescent girls and adult women is associated with adiposity and metabolic disturbances. This study examined the relationship between salivary androstenedione levels, body composition, and physical activity levels in young girls.
Method : Twenty-three girls (8.4 ± 0.9 years), nine of normal weight, and 14, overweight or obese, according to Centers for Disease Control and Prevention body mass index (BMI) percentile ranking, wore an ActiGraph® accelerometer for five days. Skin folds were measured for percentage body fat and fat-free mass calculation. Saliva samples were collected at home, three times in one day (upon waking, 30 minutes post-waking and in the evening). Previously published cut-points estimated the minutes of sedentary behaviour, light, moderate, moderate-to-vigorous, vigorous, and very vigorous physical activity. Meeting physical activity recommendations was defined as accumulating 60 minutes/day of moderate-to-vigorous physical activity. T-tests, correlation analysis, and analysis of variance, examined the relationships among the variables (alpha = p-value ≤ 0.05).
Results : Thirty-five per cent of the girls met current physical activity recommendations. There were no differences between the normal weight and overweight or obese categories in terms of meeting physical activity recommendations, or salivary androstenedione levels. Evening salivary androstenedione levels were higher among girls who did not meet the physical activity recommendations (116.9 ± 15.3 pg/ml vs. 80.45 ± 8.5 pg/ml, p-value = 0.04). Salivary androstenedione levels at 30 minutes post-waking were positively correlated with BMI (r = 0.45, p-value = 0.03) and percentage body fat (r = 0.40, p-value = 0.05).
Conclusion : These research results were similar to those of circulating androgen research performed in adolescent girls and adult women, in that salivary androstenedione levels were positively correlated with BMI and percentage body fat in young girls. Meeting physical activity recommendations was associated with the maintenance of the normal diurnal rhythm of salivary androstenedione secretion.
Author P. DiabSource: Journal of Endocrinology, Metabolism and Diabetes in South Africa 17, pp 52 –54 (2012)More Less
Medicine is both a science and an art; a delicate balancing act of scientific diagnostic reasoning and management on the one hand, and the development and nurturing of a relationship with another person, on the other. Patients seek a healthcare provider who can provide them with a service. They want someone who will provide explanations, answer their questions, and alleviate their fears. Patient adherence to chronic medication regimens is greatly improved if a bond of trust exists, to sustain a strong doctor-patient relationship.
Source: Journal of Endocrinology, Metabolism and Diabetes in South Africa 17, pp 57 –59 (2012)More Less
Background : Papillary thyroid cancer (PTC) is one of the most common thyroid malignancies, with an increase in incidence rates over the past few decades. Although the exact cause of thyroid cancer in most patients is still unclear, the possibility of genetic predisposition to PTC cannot be overlooked. Here, we report a case study of PTC, in which the family was extensively affected, with each family member diagnosed with either benign or malignant thyroid neoplasms, or functional thyroid disorder.
Method : A 57-year-old white female with a past medical history of hypothyroidism, and a significant family history of multiple thyroid cancers, was found to have new onset thyroid nodules during a routine screening ultrasound. Fine needle aspiration revealed suspicious papillary carcinoma (follicular variant). The patient underwent total thyroidectomy.
Results : The histology report revealed total colloid nodules in the right lobe with focal calcification, lymphocytic thyroiditis, and two foci of papillary microcarcinoma. The patient subsequently underwent radioactive iodine ablation therapy, along with pilocarpine and thyrogen injection.
Conclusion : This case study illustrates the need for awareness of the possibility of genetic predisposition to, as well female preponderance of, familial PTC.
Author Aslam AmodSource: Journal of Endocrinology, Metabolism and Diabetes in South Africa 17, pp 61 –62 (2012)More Less
Much has been written recently about the burden of non-communicable diseases (NCDs), and the recent United Nations High Level Summit on Non-Communicable Diseases in September 2011 served to highlight a call to action globally. One hundred and ninety-three Member States, with 34 Heads of State (including our own President), adopted the historic Political Declaration on Non-Communicable Disease Prevention and Control. This is the first ever Political Declaration on NCD, and includes 22 commitments to which governments worldwide must now be held accountable. Importantly for people with diabetes mellitus (diabetes), the Declaration commits governments to increasing access to affordable, safe, effective and quality-assured medicines and technologies. Diagnostics are equally as important as medicines for people with diabetes. Crucially, the Declaration commits governments to improve diagnostic services, including by increasing capacity of laboratory services, and collaboration with the private sector to improve affordability, accessibility and maintenance of diagnostic equipment and technologies. The central role that people with diabetes and NCDs play is made clear in the Declaration. It commits governments to a nationally driven and comprehensive response to NCDs, with the full and active participation of people living with the diseases. It also acknowledges the importance of health literacy and patient empowerment in care, and the role of patient organisations in the provision of NCD services.