oa Journal of Endocrinology, Metabolism and Diabetes in South Africa - Beta-2 microglobulin as a predictor of peripheral arterial disease in diabetes : the effect of estimated glomerular filtration : original research

Volume 17, Issue 3
  • ISSN : 1608-9677
  • E-ISSN: 2220-1009



Peripheral arterial disease (PAD) is common in patients with type 2 diabetes mellitus. Its definitive diagnosis requires ultrasound or angiography. Beta-2 microglobulin (β microglobulin) has been proposed as a diagnostic marker for PAD. The objective of the study was to evaluate the diagnostic value of β microglobulin for PAD in patients with diabetes and varying renal function.

This was a cross-sectional study.
An academic centre (University of Pretoria and Steve Biko Academic Hospital Diabetes Clinic).
One hundred and eight convenience-sampled patients.
Patients completed a questionnaire and had toe and arm blood pressure (toe-arm index), as well as serum β microglobulin and creatinine, measured.
Beta-2 microglobulin did not differ (p-value = 0.34) between those subjects with PAD (n = 43) and those without PAD (n = 65). In a linear regression model, the interaction term between estimated glomerular filtration rate categories and the inverse of β microglobulin was highly significant (p-value = 0.001).
Although the sample size was small, β microglobulin did not distinguish between subjects with and without PAD. Renal function and its effects on the association between β microglobulin and PAD need further study.

Loading full text...

Full text loading...


Article metrics loading...


This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error