oa Journal of Endocrinology, Metabolism and Diabetes in South Africa - Telangiectatic osteosarcoma, a rare complication of Paget's disease of bone : case study
|Article Title||Telangiectatic osteosarcoma, a rare complication of Paget's disease of bone : case study|
|© Publisher:||Medpharm Publications|
|Journal||Journal of Endocrinology, Metabolism and Diabetes in South Africa|
|Affiliations||1 Stellenbosch University, 2 Stellenbosch University, 3 Stellenbosch University, 4 Stellenbosch University, 5 Stellenbosch University, 6 Tygerberg Academic Hospital, 7 Tygerberg Academic Hospital, 8 Tygerberg Academic Hospital, 9 Tygerberg Academic Hospital and 10 Tygerberg Academic Hospital|
|Publication Date||Jan 2014|
|Pages||36 - 38|
|Keyword(s)||ALP, Paget's disease of bone, PDB, Serum alkaline phosphatise and Telangiectatic osteosarcoma|
Paget's disease of bone (PDB) is the second most common metabolic bone disease. This condition, characterised by abnormal bone remodelling, has a prevalence of 5-8% in patients of European ancestry over the age of 55 years. The majority of patients are asymptomatic. Diagnosis is based on the distinct radiological picture or on the elevation of serum alkaline phosphatase (ALP). Malignant sarcomatous degeneration is a rare (< 1%) and often fatal complication of PDB. Osteosarcoma is considered to be a rare and devastating complication of PDB. We report on a confirmed case of very rare telangiectatic osteosarcoma in monostotic PDB.
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