oa Journal of Endocrinology, Metabolism and Diabetes in South Africa - Telangiectatic osteosarcoma, a rare complication of Paget's disease of bone : case study



Paget's disease of bone (PDB) is the second most common metabolic bone disease. This condition, characterised by abnormal bone remodelling, has a prevalence of 5-8% in patients of European ancestry over the age of 55 years. The majority of patients are asymptomatic. Diagnosis is based on the distinct radiological picture or on the elevation of serum alkaline phosphatase (ALP). Malignant sarcomatous degeneration is a rare (< 1%) and often fatal complication of PDB. Osteosarcoma is considered to be a rare and devastating complication of PDB. We report on a confirmed case of very rare telangiectatic osteosarcoma in monostotic PDB.


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