oa Journal of Endocrinology, Metabolism and Diabetes in South Africa - Diabetic nephropathy in a tertiary care clinic in South Africa : a cross-sectional study : original research



The aim of this study was to determine the prevalence of micro- or macroalbuminuria in type 1 and type 2 diabetic patients, and to examine the relationship with the diabetes control parameters such as haemoglobin (Hb)A, blood pressure (BP) and lipids.

This was an analytical cross-sectional study.
The study consisted of 754 patients with either type 1 or type 2 diabetes, attending a diabetes clinic at the Kalafong Hospital in Pretoria, South Africa.
Micro- or macroalbuminuria and estimated glomerular filtration rate (eGFR) were the outcome measures.
An HbA > 7% was recorded in 88.9% of the patients, and low-density lipoprotein cholesterol ≥ 1.8 mmol/l in 81%. Overall, the prevalence of micro- or macroalbuminuria was 33.6%. Logistic regression revealed that HbA, the duration of diabetes, systolic BP, male sex and triglycerides were predictive of microalbuminuria.
The prevalence of micro- or macroalbuminuria in this study fell within the ranges of what has previously been reported in Africa. HbA and the duration of diabetes were the strongest predictors of microalbuminuria in all of the patients, and age was the strongest predictor of a low eGFR. Diabetes was poorly controlled, making the progression to end-stage renal failure a real concern in these patients.


Article metrics loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error