oa Journal of Endocrinology, Metabolism and Diabetes in South Africa - 40th SEMDSA, 8th LASSA and 8th DESSA Congress, 27 - 30 March 2004, Holiday Inn Durban-Elangeni, Durban : abstracts



Extracted from text ... ?-Cell Dysfunction in Type 2 Diabetes. SE Kahn. VA Puget Sound Health Care System and University of Washington, Seattle, WA, USA. Islet ?-cell function is critical in the regulation of glucose homeostasis. In type 2 diabetes, alterations in insulin production and secretion along with insulin resistance are major contributors to the development of hyperglycemia. A number of different approaches have been used to assess ?-cell function including examining the early phase secretory responses to oral or intravenous glucose challenges and the ability of the ?-cell to convert proinsulin to insulin. All these are defective in type 2 diabetes and progression of these impairments is responsible for the worsening of hyperglycemia that is observed ..


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