n Southern African Journal of Critical Care - Goal directed resuscitation - the state of play in 2004




Patients with septic shock have an improved survival if they are resuscitated within 6 hours of presentation to a central venous oxygen saturation of at least 70%. Oxygen delivery to tissues is determined by cardiac output, haemoglobin and arterial oxygen saturation. Strategies to improve oxygen delivery include intravenous fluids, blood transfusion and inotropic drugs; however, these therapies all carry inherent risks. Balancing these risks with the goal of achieving rapid restoration of tissue oxygenation is the key to successful therapy in shock.


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