n South African Journal of Child Health - Risk factors for mortality in neonatal seizure in a Nigerian newborn unit

Volume 1, Issue 2
  • ISSN : 1994-3032
  • E-ISSN: 1999-7671



To determine the risk factors for mortality in neonatal seizures.

A prospective study of consecutive newborn babies with seizures admitted to a Nigerian hospital between January and December 2006. Multiple regression analysis was used to determine the risk factors for mortality among consecutive neonates admitted with seizures.
Seventy-eight babies were studied. Thirty-six of these (46.1%) had seizures within the first 24 hours of life. The mean age at onset of seizure was 85.4 ± 106.1 hours. The leading aetiologies included hypocalcaemia 65.4%), hypoxic-ischaemic encephalopathy (HIE) (60.3%) and hypoglycaemia (50.0%). Severe anaemia occurred in 56.4% of babies. Most (85.9%) had multiple aetiologies while no aetiology was identified in 5.1%. The mortality rate was 43.6%. Significant risk factors for mortality included duration of seizure longer than 24 hours (p = 0.019), hypoglycaemia (p = 0.001) and severe anaemia (p = 0.004). The co-existence of HIE with hypoglycaemia and hypocalcaemia was also more significantly associated with mortality (p = 0.03) than each of hypoglycaemia and hypocalcaemia co-existing with HIE separately.
The prevention of fatal neonatal seizures should start with good intrapartum care, prompt detection and correction of hypoglycaemia and anaemia and early control of seizures.

Loading full text...

Full text loading...


Article metrics loading...


This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error