n South African Journal of Child Health - Vaccines, immunisation and HIV disease : review




Aspects of immunisation of the HIV-infected person that need to be considered include safety, efficacy with or without highly active antiretroviral therapy (HAART), convenience and relevance to public health. Live attenuated vaccines have been associated with an increased risk of disseminated disease, while killed and subunit vaccines have been shown to be safe. HIV-infected individuals have suboptimal immunological responses to primary vaccination, including memory and protection, and a faster rate of immunological decline of primary vaccine responses. Despite this, there is clear evidence to support vaccination of these individuals as they have a high burden of vaccine-preventable diseases. Immunisation schedules should be universal for all children. Surveillance and monitoring of the vaccinated HIV-infected individual are essential to evaluate responses to and risks associated with vaccination. HAART has a positive effect on rates of response to vaccination.


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