n Southern African Journal of HIV Medicine - Abacavir: its use and hypersensitivity : clinical

Volume 10, Issue 4
  • ISSN : 1608-9693
  • E-ISSN: 2078-6751



Abacavir, a nucleoside reverse transcriptase inhibitor, is useful in first- and second-line HIV therapy and as a substitute for stavudine and zidovudine when toxicity is a problem. Although it is safe and well tolerated, a life threatening hypersensitivity reaction can occur. The risk for developing this reaction relates to the presence of specific genotypes, especially HLA-B*5701.

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