n Southern African Journal of HIV Medicine - Abacavir: its use and hypersensitivity : clinical
|Article Title||Abacavir: its use and hypersensitivity : clinical|
|Journal||Southern African Journal of HIV Medicine|
|Author||Helena Rabie, Kristin Lorenc Henning, Pierre Schoeman, Nico De Villiers, G.H.J (Oubaas) Pretorius and Mark F. Cotton|
|Publication Date||Dec 2009|
|Pages||81 - 84|
Abacavir, a nucleoside reverse transcriptase inhibitor, is useful in first- and second-line HIV therapy and as a substitute for stavudine and zidovudine when toxicity is a problem. Although it is safe and well tolerated, a life threatening hypersensitivity reaction can occur. The risk for developing this reaction relates to the presence of specific genotypes, especially HLA-B*5701.
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