n Southern African Journal of HIV Medicine - When to start antiretroviral therapy in adults : the results of HPTN 052 move us closer to a 'test-and-treat' policy : opinion

Volume 12, Issue 3
  • ISSN : 1608-9693
  • E-ISSN: 2078-6751



When is the best time to initiate antiretroviral therapy (ART) in adults? This is a vital question in HIV treatment and prevention services. More specifically, is the 350 cells/µl CD4 count threshold recommended by current World Health Organization (WHO) guidelines sufficient, or should we move to a 'test-and-treat' approach in which anyone who tests HIV-positive is offered ART, irrespective of their CD4 count? The recently announced results of the HPTN 052 trial take us closer, but not all the way, to a test-and-treat approach.

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