n Southern African Journal of HIV Medicine - Low-dose stavudine trials : a public health priority for developing countries : debate
|Article Title||Low-dose stavudine trials : a public health priority for developing countries : debate|
|Journal||Southern African Journal of HIV Medicine|
|Affiliations||1 University of the Witwatersrand, 2 Charlotte Maxeke Johannesburg Academic Hospital, 3 Tygerberg Children's Hospital, 4 Tygerberg Children's Hospital, 5 Stellenbosch University and 6 Stellenbosch University|
|Publication Date||Mar 2012|
|Pages||20 - 21|
The debate around relooking at stavudine dosing, both in terms of the adult low-dose stavudine study and more broadly, is welcome. The study being proposed to evaluate low-dose stavudine v. tenofovir is a fairly standard placebo-controlled non-inferiority study. The study design is not controversial; however, the choice of study drug has attracted critical attention. We have previously discussed the issue of stavudine use, cost and access, and the significant implications of stavudine in developing countries, in detail in a recent article. We continue to believe that low-dose stavudine clinical trials, in both adults and children, are a priority for developing countries. These studies are being proposed simply because tenofovir is very expensive, and the only available cheaper alternative is stavudine.
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