n Southern African Journal of HIV Medicine - Low-dose stavudine trials : a public health priority for developing countries : debate

Volume 13, Issue 1
  • ISSN : 1608-9693
  • E-ISSN: 2078-6751



The debate around relooking at stavudine dosing, both in terms of the adult low-dose stavudine study and more broadly, is welcome. The study being proposed to evaluate low-dose stavudine v. tenofovir is a fairly standard placebo-controlled non-inferiority study. The study design is not controversial; however, the choice of study drug has attracted critical attention. We have previously discussed the issue of stavudine use, cost and access, and the significant implications of stavudine in developing countries, in detail in a recent article. We continue to believe that low-dose stavudine clinical trials, in both adults and children, are a priority for developing countries. These studies are being proposed simply because tenofovir is very expensive, and the only available cheaper alternative is stavudine.

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