n Southern African Journal of HIV Medicine - Tuberculosis prevention in HIV-infected pregnant women in South Africa : forum
|Article Title||Tuberculosis prevention in HIV-infected pregnant women in South Africa : forum|
|Journal||Southern African Journal of HIV Medicine|
|Affiliations||1 University of the Witwatersrand and 2 University of the Witwatersrand|
|Publication Date||Nov 2012|
|Pages||182 - 184|
The high burden of HIV and tuberculosis (TB) among pregnant women in South Africa contributes to a high maternal mortality rate. Isoniazid preventive therapy (IPT) is recommended for the prevention of active TB in HIV-infected individuals, including pregnant women. However, there are few data regarding IPT use in the latter, with concern regarding the concurrent use of IPT with nevirapine in pregnancy, as both treatments are hepatotoxic. The benefit and safety of IPT in HIV-infected pregnant women has not been established. We recommend a simplification of HIV and TB interventions by providing triple antiretroviral therapy to all HIV-infected pregnant women.
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