n Southern African Journal of HIV Medicine - HIV & TB Drug Resistance & Clinical Management Case Book, T. Rossouw, R.J. Lessells, T. de Oliveira : book review

Volume 14, Issue 2
  • ISSN : 1608-9693
  • E-ISSN: 2078-6751



South Africa (SA) is home to the highest number of HIV-infected people in any country, and has the largest HIV treatment program worldwide, with 2 million patients currently receiving combination antiretroviral therapy (ART). The country also has a massive tuberculosis (TB) epidemic, and TB/HIV co-infection is a common challenge for clinicians. The increasing number of patients who are infected with drug-resistant strains of TB and/or HIV in Southern Africa poses a mounting threat to successful treatment. Drug-resistance testing for patients failing therapy is available at reference laboratories, which contrasts the situation in many countries in sub-Saharan Africa. This provides an important tool to protect the sustained effectiveness of available TB and HIV therapies; however, interpretation of drug resistance reports is complex and expert guidance to clinicians may be required for optimal clinical management.

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