n Southern African Journal of HIV Medicine - Consensus statement : management of drug-induced liver injury in HIV-positive patients treated for TB : guideline
|Article Title||Consensus statement : management of drug-induced liver injury in HIV-positive patients treated for TB : guideline|
|Journal||Southern African Journal of HIV Medicine|
|Affiliations||1 University of the Witwatersrand, 2 University of the Witwatersrand, 3 University of the Witwatersrand, 4 University of the Witwatersrand, 5 University of KwaZulu-Natal and 6 University of Cape Town|
|Publication Date||Sep 2013|
|Pages||113 - 119|
Drug-induced liver injury (DILI) in HIV/tuberculosis (TB) co-infected patients is a common problem in the South African setting, and re-introduction of anti-TB drugs can be challenging for the healthcare worker. Although international guidelines on the re-introduction of TB treatment are available, the definition of DILI is not uniform, management of antiretroviral therapy (ART) in HIV co-infection is not mentioned, and the guidance on management is not uniform and lacks a practical approach. In this consensus statement, we summarise important aspects of DILI and provide practical guidance for healthcare workers for different patient groups and healthcare settings on the re-introduction of anti-TB drugs and ART in HIV/TB co-infected individuals presenting with DILI.
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