n Southern African Journal of HIV Medicine - Neuroendocrine tumour in a patient with neurofibromatosis type 1 and HIV : case report
|Article Title||Neuroendocrine tumour in a patient with neurofibromatosis type 1 and HIV : case report|
|Journal||Southern African Journal of HIV Medicine|
|Affiliations||1 University of Pretoria and 2 University of the Witwatersrand|
|Publication Date||Apr 2015|
|Pages||1 - 4|
We report the case of an HIV-positive female patient with neurofibromatosis type 1 who was treated for recurrent peptic ulcer disease and later developed diabetes mellitus and chronic diarrhoea. A metastasising somatostatinoma was histologically proven and evidence of a concomitant gastrin-producing neuroendocrine tumour was found. Neuroendocrine tumours (NETs) are very rare neoplasms originating from a wide variety of endocrine and nervous system tissue with the ability to produce different hormones. A somatostatin- and gastrinsecreting NET in a patient with HIV has not been reported in the literature, to the best of our knowledge. We discuss oncogenic pathomechanisms related to the underlying conditions and propose stringent monitoring for tumours in HIV-positive patients with phakomatoses as well as initiation of antiretroviral therapy.
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