n Southern African Journal of HIV Medicine - Therapy developments in southern Africa : immune response and structured treatment interruptions in HIV-1-infected individuals treated with antiviral therapy : research and ethics

Volume 2, Issue 1
  • ISSN : 1608-9693
  • E-ISSN: 2078-6751



Progress in the field of HIV treatment and the prevention of AIDS-related complications has led to a significant decline in mortality and morbidity in developed countries. Limitations of the currently available antiviral therapies include the cost of treatment, metabolic complications of treatment, and the development of viral resistance. The development of resistant viral strains is related to difficulties with compliance, recognition of ongoing viral replication despite undetectable serum viral loads, poor drug penetration into sanctuary sites, and the discovery that resting CD4 cells can provide a reservoir for HIV-1 with a predicted decay rate of approximately 60 years. The chance of achieving viral eradication with currently available treatment options appears to be very small. Therefore strategies involving sustained treatment with enhancement of HIV-specific immune control mechanisms need to be investigated.

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