n Southern African Journal of HIV Medicine - Lower respiratory tract infections in HIV-1-infected South African children : kiddies corner

Volume 2, Issue 3
  • ISSN : 1608-9693
  • E-ISSN: 2078-6751



Lower respiratory tract infections (LRTI) are the leading cause of childhood morbidity and mortality in developing countries. The human immunodeficiency virus type 1 (HIV) epidemic has worsened the global burden of LRTI. Statistics from one South African hospital confirm the strong association between the two. Almost half [46%) of all children requiring hospitalisation for severe LRTI were HIV-infected, while these children accounted for 84% of all deaths from LRTI. There are also differences in the spectrum of pathogens causing LRTI in HIV-infected and uninfected children. This review describes the burden of severe LRTI in South African children and appraises the existing data on the potential for interventions to reduce both disease and mortality in these children.

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