n Southern African Journal of HIV Medicine - The merits and place of resistance testing in the management of HIV-infected patients : laboratory
|Article Title||The merits and place of resistance testing in the management of HIV-infected patients : laboratory|
|Journal||Southern African Journal of HIV Medicine|
|Publication Date||Jan 2001|
|Pages||13 - 18|
The mutation rate in the HN genome is high because the HIV reverse transcriptase (Rn does not possess DNA 'proofreading' activity and is consequently highly error prone. During the synthesis of double-stranded DNA from the RNA template, mutations may appear owing to substitution of one nucleotide base for another, giving rise to amino acid substitutions in the viral protein for which the gene encodes. Insertions and deletions occur less commonly.
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