n Southern African Journal of HIV Medicine - Neurological manifestations of HIV infection in adults - an overview : neurology

Volume 2, Issue 4
  • ISSN : 1608-9693
  • E-ISSN: 2078-6751



HIV is a neutrophic virus. It is therefore not surprising that neurological symptoms are widely prevalent following infection, Peripheral and central nervous system (CNS) symptoms are common, frequently debilitating, and often life-threatening. These occur throughout the natural history of HIV-related illness, from seroconversion through to full-blown immunodeficiency disease. It is estimated that between 40% and 70% of persons infected with the HIV virus develop symptomatic neurological disturbances. In autopsy neuropathological studies. CNS abnormalities are found to occur in up to 90% of patients with advanced AIDS. Most of the information available to clinicians in South Africa comes from literature from the USA or Europe, despite the fact that we see a vast amount of HIV-related neurology. The aim of this article is to give an overview of the clinical neurological manifestations of HIV, to provide more detail on a few conditions that we see commonly, and to highlight South African neuro-HIV research.

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