n Southern African Journal of HIV Medicine - Immune restoration in the context of HAART

Volume 2004, Issue 14
  • ISSN : 1608-9693
  • E-ISSN: 2078-6751



The advent of highly active antiretroviral combination therapy (HAART) has resulted in significantly improved survival of patients and a reduction in the progression of human immunodeficiency virus (HIV) infection. <br>At the root of these clinical benefits is a dramatic reduction in HIV viral load HAART induces a sustained effective suppression of HIV replication in most patients and leads to a preservation or restoration of immune function. <br>The restoration of an impaired immune system is assessed by clinical parameters, immunological changes which can be measured in the laboratory and a marked reduction in the morbidity and mortality of patients<br>To understand the features of immune restoration it is necessary to review the immunopathogenesis of HIV infection and highlight areas where improvement of function occurs with HAART.

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