n Southern African Journal of HIV Medicine - New antiretroviral drugs : what's on the horizon in 2005? : pharmacology




Despite the present number of available antiretrovirals (ARVs), there continues to be a need for new medications with improved tolerability, and activity against resistant virus. This article will review three groups of ARVs: those available in North America and Europe but not yet registered in South Africa; new formulations of drugs for which the parent formulations are already available in South Africa; and promising new compounds in early clinical stages of development. Table I shows the year of approval of ARVs available for treatment of HIV-infected individuals, in both the USA and South Africa and Table II summarises the characteristics and rationale for new ARVs.


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