n Southern African Journal of HIV Medicine - Changing antiretroviral therapy in paediatric patients

Volume 2005, Issue 21
  • ISSN : 1608-9693
  • E-ISSN: 2078-6751



An important principle in treating patients with HIV is that the first regimen is your best chance for success. So get it right the first time. Historically children have always lagged behind adults in their (virological) response to antiretrovirals (ARVs). However, with improvements in knowledge about pharmacokinetics, adherence and newer more potent and tolerable drugs in children, response to therapy in children is now approximating that in adults. Nevertheless, it is inevitable that over time, for a variety of reasons, a significant number of patients will need to move to a second-line regimen. For this reason, it is important that we have an approach to changing therapy.

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