n Southern African Journal of HIV Medicine - Paediatric antiretroviral pharmacology

Volume 2005, Issue 21
  • ISSN : 1608-9693
  • E-ISSN: 2078-6751



Half of the ARV agents available worldwide have paediatric approval, but many are without ideal paediatric formulations. Pharmacokinetic differences in paediatric populations require careful attention to dosing and concomitant therapies. Importantly, ARV therapy can be limited by short-term and long-term toxicity and drug interactions. <br>Low-cost, sustained and consistent access to ARV therapy is necessary to combat the HIV epidemic. For optimal response &gt; 90 - 95% adherence to ARVs is required. This requires that extensive education and support resources be provided in addition to the ARV medications themselves. Paediatric patients receiving ARV therapy require ongoing monitoring to ensure tolerability, dose adjustments with advancing age, acceptability and therapeutic success.

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