n Southern African Journal of HIV Medicine - Virological response without CD4 recovery : case study
|Article Title||Virological response without CD4 recovery : case study|
|Journal||Southern African Journal of HIV Medicine|
|Author||Ayanda Madide, Helena Rabie and Mark Cotton|
|Publication Date||Sep 2006|
|Pages||45 - 47|
The objective of antiretroviral therapy (ART) is to suppress viral replication so that immune restoration can occur. Failure of immune restoration is usually associated with poor virological suppression. In children a good immunological and clinical response to ART is often achieved despite incomplete viral suppression. However, we have recently managed a number of children in whom immune restoration did not occur despite excellent virological suppression. We present a case, discuss possible causes and speculate on the appropriate course of action.
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