n Southern African Journal of HIV Medicine - A patient with multiple IRIS : case study

Volume 2007, Issue 28
  • ISSN : 1608-9693
  • E-ISSN: 2078-6751



The immune reconstitution inflammatory syndrome (IRIS) is a frequent early complication of antiretroviral therapy (ART), particularly in patients who commence ART with low CD4 counts and established opportunistic infections. IRIS results from a pathological inflammatory response to pre-existing infective, host or other antigens, alive or dead, causing clinical deterioration in HIV-infected patients after initiating ART. A case definition for IRIS is shown in Table I. The most common forms of IRIS described occur in association with mycobacterial and herpesvirus infections. We describe here a patient who presented with IRIS in association with tuberculosis (TB), then cryptococcosis, and later varicella zoster virus (VZV).

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