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- Southern African Journal of HIV Medicine
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- Volume 2008, Issue 29, Summer 2008
Southern African Journal of HIV Medicine - Volume 2008, Issue 29, Summer 2008
Volumes & issues
Volume 2008, Issue 29, Summer 2008
AIDS Therapy e-dition, 3rd edition, by Raphael Dolin, Henry Masur, and Michael S. Saag : book reviewSource: Southern African Journal of HIV Medicine 2008 (Summer 2008)More Less
Author Des MartinSource: Southern African Journal of HIV Medicine 2008 (Summer 2008)More Less
It has been both an honour and a privilege for me to have been a colleague and friend of this remarkable clinician for the past two decades. An outline of his career provides valuable insights as to his beliefs, philosophies and guiding principles, which have evolved over time.
Source: Southern African Journal of HIV Medicine 2008, pp 8 –10 (Summer 2008)More Less
Scaling up of antiretroviral therapy (ART) in developing countries would not have been possible without market competition, which has driven down the price of standard first-line antiretroviral (ARV) drugs from more than US$12 000 per person / year in 2000 to US$99 today. However, access to newer, second-line ARVs remains largely restricted to originator (patented) drugs. This causes significant challenges in countries where access to newer medicines is becoming increasingly important as programmes mature and face challenges related to drug toxicity and resistance. Toxicity in particular has emerged as a major reason for individual drug switches and regimen changes, and is strongly implicated in decreasing adherence.
This article focuses on international efforts to reduce the price of tenofovir, and outlines the implications of these dynamics for South Africa.
Source: Southern African Journal of HIV Medicine 2008, pp 12 –17 (Summer 2008)More Less
There is a wide clinical spectrum of renal disease in the course of HIV infection, which includes potentially reversible acute renal failure (ARF) (more recently known as acute kidney injury), electrolyte and acid-base disturbances, and intrinsic renal disease unrelated to HIV itself (e.g. co-morbid diabetes mellitus and hypertension). In addition, there is the group of HIV-associated glomerulonephropathies that may present with acute or chronic renal failure. Histologically, this group is divided into the 'classic' HIV-associated nephropathy (HIVAN) with focal segmental glomerulosclerosis (HIV-FGS), HIV-associated immune complex disease (HIV-IC), and HIV-associated thrombotic thrombocytopenic purpura / haemolytic uraemic syndrome (HIV-TTP / HUS). It is this group that is primarily implicated in the burden of chronic kidney disease (CKD) in the HIV-infected population.
Source: Southern African Journal of HIV Medicine 2008, pp 18 –31 (Summer 2008)More Less
These guidelines are intended as an update to those published in the Southern African Journal of HIV Medicine of March 2005 (issue 18, pp.18 - 31). Since the previous guidelines, the scale-up of antiretroviral therapy (ART) in the region has expanded considerably. Cohort studies from the region show excellent clinical outcomes, but ART is still being started in advanced disease and early death rates remain high. New data have become available on antiretroviral (ARV) tolerability in the region and several new ARV drugs have become available. Important new sections have been added on ART use in special populations, including pregnancy and hepatitis B co-infection.
Nutrition and HIV / AIDS : nutritional guidelines for HIV-infected adults and children in Southern Africa : meeting the needs : guidelinesSource: Southern African Journal of HIV Medicine 2008, pp 34 –59 (Summer 2008)More Less
Enhancing PMTCT programmes through psychosocial support and empowerment of women : the mothers2mothers model of care : short reportSource: Southern African Journal of HIV Medicine 2008, pp 60 –64 (Summer 2008)More Less
In 2006, more than half a million children were newly infected with HIV, most from mother-to-child transmission (MTCT) in resource-limited countries. The global figures are staggering: every day, 1 400 children under the age of 15 die from AIDS-related illnesses. Of the 2.3 million children currently infected with HIV, most will die without treatment within the first 5 years of life - more than half before the age of 2. Even children not infected with HIV are affected by the epidemic: 15 million children have lost one or both parents to AIDS, and these children are more likely to experience poverty, homelessness and early death.