n Southern African Journal of HIV Medicine - Management of cancer in patients with HIV : clinical practise




As the incidence of HIV increases in Africa the coincidental infection of cancer patients will rise. Owing to the effects of HIV on haemopoiesis and immune function, HIV infection of patients with cancer poses management difficulties for both the physician managing the cancer and the physician managing the HIV infection. For most cancers, the dose intensity (total dose over total time) of the chemotherapy or radiotherapy is strongly associated with response rates. This is even more noticeable in haematological malignancies and cancers with curable potential. Maintaining dose intensity in the presence of HIV requires control of the HIV infection and frequently the use of external growth factor support, especially in intensive regimens. It is not usually appropriate to attempt anything except palliative treatment if these resources are not available.


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