n Southern African Journal of HIV Medicine - Using antiretroviral therapy in patients with tuberculosis : TB and ART




Tuberculosis is the commonest cause of morbidity and mortality in HIV-infected patients in sub-Saharan Africa. With increasing access to antiretroviral therapy in the region, it is inevitable that large numbers of patients will either develop tuberculosis while on antiretroviral therapy or be considered for antiretroviral therapy when tuberculosis develops. There are complex drug interactions and shared toxicity of antiretroviral and tuberculosis therapy that need to be considered. Furthermore, antiretroviral therapy can lead to paradoxical deterioration of tuberculosis. This article reviews these complex interactions and provides recommendations for using antiretroviral and tuberculosis therapy in the southern African context.


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