n Southern African Journal of HIV Medicine - Immune reconstitution : immune reconstitution

Volume 3, Issue 2
  • ISSN : 1608-9693
  • E-ISSN: 2078-6751



In most HIV-infected patients commencing highly active antiretroviral therapy, viral load is reduced and with this subsequent immune restoration begins. Studies have shown that CD4+ T cells increase soon after therapy commencement, with the largest increase occurring in the first 3 months and the increase reducing in the 2nd and 3rd years. Immune reconstitution occurs even in those patients in whom severe immune suppression has occurred.

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