n Southern African Journal of HIV Medicine - Case study - a second opinion on management

Volume 9, Issue 3
  • ISSN : 1608-9693
  • E-ISSN: 2078-6751



Patients diagnosed with tuberculosis (TB) and then commenced on antiretroviral therapy (ART) are often on several drugs that can cause a hypersensitivity drug reaction. Such reactions may take the form of a drug rash (which may evolve to a Stevens-Johnson syndrome or toxic epidermal necrolysis), hepatitis, a drug fever or a combination of these. These reactions result in considerable morbidity directly and indirectly because they cause interruptions in optimal treatment for the TB and HIV.

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