n Southern African Journal of HIV Medicine - Severe rhabdomyolysis following co-administration of simvastatin and fluconazole in an HIV-positive man : case study
|Article Title||Severe rhabdomyolysis following co-administration of simvastatin and fluconazole in an HIV-positive man : case study|
|Journal||Southern African Journal of HIV Medicine|
|Author||Malaki Ramogi, Manjula Pammi and Chris J. Bignell|
|Publication Date||Winter 2008|
|Pages||53 - 54|
We report a case of rhabdomyolysis and acute renal failure in a 43-year-old man newly diagnosed with HIV and hepatitis B co-infection. Rhabdomyolysis was possibly induced by co-administration of simvastatin and fluconazole. Underlying hepatitis may have increased the risk of rhabdomyolysis by decreasing the metabolism of simvastatin. Few case reports link the development of rhabdomyolysis with the co-administration of these two drugs. This case calls for extra pharmacovigilance with proper patient education when prescribing drugs with potential for adverse interactions.
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