n South African Journal of Obstetrics and Gynaecology - New anabolic agents in the treatment of osteoporosis : editorial

Volume 10, Issue 1
  • ISSN : 0038-2329
  • E-ISSN: 2078-5135



Extracted from text ... SAJOG Osteoporosis is a common, serious disease characterised by a low bone mass and microarchitectural deterioration resulting in bone fragility and an increased risk of fracture.1,2 The mainstay of current therapies for osteoporosis is antiresorptive agents like calcium and vitamin D, oestrogen, selective oestrogen receptor modulators (SERMs), the bisphosphonates and calcitonin. These drugs inhibit osteoclast-mediated bone loss, reduce bone turnover (both resorption and formation), and modestly (less than 10%) increase bone mineral density (BMD). They reduce but do not eliminate fracture risk, and do not restore lost bone structure.3,4 Ideally, antiresorptive drugs should be employed to prevent osteoporosis, whereas osteoanabolic agents, either alone or in combination with antiresorptives, should be used to treat ..

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