n South African Journal of Obstetrics and Gynaecology - News




Extracted from text ... February 2004, Vol. 10, No. 1 SAJOG NEWS 2 PREVENTION OF PROGRESSION FROM PRECOCIOUS PUBARCHE TO POLYCYSTIC OVARY SYNDROME Girls with low birth weight (LBW) and with a history of precocious pubarche in childhood (PP) are at high risk of polycystic ovary syndrome (PCOS) in adolescence. The Journal of Pediatrics (2004; 1: 23-29) reports that a study was conducted to examine whether initiation of insulin sensitisation therapy early after menarche could prevent progression of PCOS features in formerly LBW-PP girls. Twenty-four girls, small at term birth (mean weight 2.4 kg), who presented with PP (at mean age 6.7 years) and were currently (mean age 12.4 years) postmenarcheal, with hyperinsulinaemic hyperandrogenaemia but were not obese, were randomly assigned to receive metformin (850 mg/d) or no treatment for 12 months. Six-month fasting ..


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