n South African Journal of Obstetrics and Gynaecology - Misoprostol in obstetrics and gynaecology - benefits and risks




Misoprostol is currently being used for induction of labour at or near term and also for termination of pregnancy. Its use without proven dosage regimens is possibly associated with an increase in the incidence of uterine hyperstimulation, preterm labour, induced abortion above 20 weeks' gestation, meconium-stained liquor in the latent phase of labour, fetal distress and cases of uterine rupture as demonstrated by these case reports and literature review. Its use for these purposes must be under controlled circumstances, using minimum doses.


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